A dividing cell from non-living parts. “It’s a big step forward to this holy grail of making a living thing out of dead components.” Researchers packed lab-made biomolecules into a membrane, then watched the synthetic cell grow, copy DNA, and […]
Guy in garage lab testing a new Alzheimer’s drug. “I designed and synthesized PAC-832 in a chemistry lab I built in my garage.” Douglas Yao walks through PAC-832, “the world’s first selective GalR1 antagonist,” plus why targeting galanin signaling might […]
What if humans could regrow tissue? “[The genes are] already there — you just need to learn how to get them to behave the way you want.” Texas A&M researchers used a two-step sequence of growth factors to regrow mice […]
The cancer Alzheimer’s disease paradox. “paradoxically, the risk of AD in patients with cancer is reduced by 25–35%. Conversely, the risk of cancer in patients with AD is halved.” ~ learn more
This specially-designed jacket pulls drinking water from thin air. “The textile incorporated into the jacket collects moisture and funnels it to detachable harvesting units. Those units are placed in a foldable collector piece and heated to produce water. The jacket […]
Manufacturing requirements are killing cell and gene therapy. Ruxandra Teslo argues that for CAR-T, paperwork-level thresholds and noisy tests can block drugs that still work, and turn manufacturing into the real bottleneck. “Legend Biotech’s leadership later calculated that if those […]
Universal mortality signatures. Dense reading. The important bit is that researchers found a couple genes across multiple species that highly correlate with aging. “We developed rodent multi-tissue clocks of chronological age and expected mortality and decomposed them into co-regulated modules […]
Some people resist GLP-1 drugs. “More GLP-1 was needed to have the same biological effect, meaning they were resistant to GLP-1.” Stanford-led researchers found about 10% of people carry PAM gene variants tied to weaker blood sugar improvements on GLP-1 […]
Magic mushrooms’ remarkable impact on Alzheimer’s patient. “Approximately 19 h post-administration, spontaneous autobiographical speech emerged.” A Frontiers in Neuroscience case report describes a woman with advanced Alzheimer’s who showed days to weeks of temporary improvements after a high-dose psilocybin mushroom session, […]
One-shot gene editing for LDL. “One dose of VERVE-102 led to dose-dependent, substantial, and sustained reductions in PCSK9 and LDL cholesterol levels.” It is a phase 1 study in 35 people, with LDL reductions up to 62% at the highest […]