under the microscope

A large language model for complex cardiology care.

A large language model for complex cardiology care. “In our RCT, general cardiologists’ clinical assessments aided by AMIE were preferred overall, saved time in 50.5% of cases and had fewer clinically significant errors and fewer omissions of important content.” This […]

under the microscope

Hair remembers toxic history.

Hair remembers toxic history. “back when the regulations were absent, the lead levels were about 100 times higher than they are after the regulations.” University of Utah scientists analyzed hair samples going back to 1916 and watched lead levels collapse […]

under the microscope

Mouse Alzheimer’s reversed in new study.

Mouse Alzheimer’s reversed in new study. “Remarkably, not only did preserving NAD+ balance protect mice from developing AD, but delayed treatment in mice with advanced disease also enabled the brain to fix the major pathological events driven by the disease-causing […]

under the microscope

Peanut allergy treatment progress.

Peanut allergy treatment progress. “The median tolerated dose increased from 30 mg (equivalent to approximately 1/8th of a peanut) to 3000 mg (12 peanuts) at the exit challenge, representing a 100-fold increase.” This phase II trial shows promising results for peanut oral […]

under the microscope

The evolution of bacteria.

The evolution of bacteria. “The longest-running and most celebrated of modern evolution experiments is the appropriately named Long-Term Evolution Experiment (LTEE). Started by Richard Lenski in 1988 at the University of California, Irvine, and continuing in the hands of Jeffrey […]

under the microscope

The power of surrogate endpoints.

The power of surrogate endpoints. “Surrogate endpoints: measurable intermediate biological signals that reliably predict clinical benefit, such as biomarkers or imaging readouts.” By utilizing these proxies, clinical trials can be significantly expedited, decreasing costs and increasing efficiency in drug development. […]