big ideas

UFOs are the easy belief.

UFOs are the easy belief. “UFOs haven’t been disproven, whereas the blank slate has been disconfirmed nearly 3,000 times.” Jehan Azad argues that some respectable-sounding views (CICO denial, anti-building housing takes, tabula rasa) contradict entire fields more directly than aliens […]

teaching the kids

How AI killed student writing (and revived it).

How AI killed student writing (and revived it). From NYT: “High school and college teachers are watching students write, in the classroom, in order to protect against the incursion of artificial intelligence.” I, for one, am sad to have missed […]

thoughts of food

Dyson strawberries in the supermarket.

Dyson strawberries in the supermarket. “WOW!! First time seeing @Dyson strawberries in the supermarket. Fully nerding out and losing my mind”. Fruit from your favorite vacuum maker! ~ learn more

under the microscope

Magic mushrooms’ remarkable impact on Alzheimer’s patient.

Magic mushrooms’ remarkable impact on Alzheimer’s patient. “Approximately 19 h post-administration, spontaneous autobiographical speech emerged.” A Frontiers in Neuroscience case report describes a woman with advanced Alzheimer’s who showed days to weeks of temporary improvements after a high-dose psilocybin mushroom session, […]

under the microscope

Some people resist GLP-1 drugs.

Some people resist GLP-1 drugs. “More GLP-1 was needed to have the same biological effect, meaning they were resistant to GLP-1.” Stanford-led researchers found about 10% of people carry PAM gene variants tied to weaker blood sugar improvements on GLP-1 […]

under the microscope

Universal mortality signatures.

Universal mortality signatures. Dense reading. The important bit is that researchers found a couple genes across multiple species that highly correlate with aging. “We developed rodent multi-tissue clocks of chronological age and expected mortality and decomposed them into co-regulated modules […]

retail therapy

Stories without amplification are hobbies.

Stories without amplification are hobbies. “Stories without amplification are hobbies.” Avinash Kaushik’s take on TikTok: organic reach hits a ceiling, so you need to pay to amplify the right creator stories, at real scale. ~ learn more

better doing

Grindslop.

Grindslop. “In a grindslop company, the hours are the output.” Will Manidis draws a clean line between hard companies that work long hours to build something, and a darker version where suffering becomes the product and gets performed for status. […]

better doing

The new career flex.

The new career flex. “Now, the real flex is going back to being an Individual Contributor.” Elena Verna argues the ladder got weird when headcount became the signal of impact, and introduces the “High-Impact Individual Contributor” who can ship end-to-end […]