“As with startups, biotech companies have high failure rates: 90% of clinical programs fail to receive FDA approval, while 92% of biotech companies are unprofitable at any given time.” | learn more
This is a 2007 essay from Marc Andreessen. “The most important thing you need to know going into any discussion or interaction with a big company is that you’re Captain Ahab, and the big company is Moby Dick.” | learn more
I’m only now learning about this Speiser’s approach – it’s fascinating! “Speiser currently has a roughly 20% hit rate of his companies achieving multi-billion dollar valuations.” | learn more
In 2018 this startup raised $1 billion at inception. It caused Steve Blank to ask Is the lean startup dead? Then we saw the fat startup’s launch teaser in January of this year. Here, the story ends, as “the first high-profile casualty of […]
“I joined Stripe four years ago to make starting an Internet business easier, mostly by work on Stripe Atlas. This has been a series of adjustments for me: to working as an employee, to experiencing hypergrowth, to being closer to […]
“At launch, the Waymo One app-based robotaxi service had a trained vehicle operator assigned to every vehicle, ready to take over if needed. Now Waymo is ditching the safety driver and opening up a fully driverless service to the public […]
“Spotify, the audio market, and the negative churn Consumer SaaS company.” | learn more
I’ve been casually following Opendoor since they were just a tiny startup buying and selling houses in Arizona. Now they’re about to go public via a SPAC at a $4.8 billion valuation. Here’s the bull case for “the Amazon of […]
From team a16z bio: “As our engineering toolkit in bio expands to be more powerful than ever before, and the infrastructure to deliver, produce, and scale these solutions comes increasingly online, a whole new world of problems in biology begin […]
“Side hustles can grow and evolve, but to work they need to have a few traits. They need to: Solve a problem someone is already aware of, NOT require a lot of maintenance or hand-holding, Have a no-brainer path to […]