retail therapy

Supreme Court to decide on online sales tax. 

“Internet Retailer asked retailers and consumers how they think a ruling—expected by the end of June after arguments this spring—will impact them.” Notably, this isn’t impactful for Amazon because they already collect sales tax everywhere. It’s also inevitable, in my […]

big ideas

Biology, the new (old) technical debt. 

Vijay Pande writes on the a16z blog about the transition we’re going through in healthcare. “When you finally understand the spaghetti code of bio, what can you do with it? The answer is that we’re living in a new age […]

thoughts of food

Mimicking the fasting mimicking diet. 

Rather than pay the steep price for Dr. Longo’s ProLon program, Bob from QuantifiedBob.com recreated his own version from the original patent filing. Then, he recorded all of his bio-metrics for the 5-day experiment. | learn more

under the microscope

New research has potential to prevent celiac reactions. 

Warning: this is dense technical reading. “Thus, through identification of a natural enzyme with the pre-existing qualities relevant to an ultimate goal and redefinition of its substrate specificity using computational modeling, we were able to generate an enzyme with potential […]

better doing

The best way to lose $5B dollars. 

This post tells the story of how the Vanderbilt family went from a consolidated $5B fortune in 1886 to not a millionaire among them in 1973. It’s advice on what not to do. | learn more