Coding with LLMs in the summer of 2025. “Despite the large interest in agents that can code alone, right now you can maximize your impact as a software developer by using LLMs in an explicit way, staying in the loop. […]
Where are all the trillion dollar biotechs? Despite countless innovations, biotech is plagued by shrinking returns. The approval of new drugs per billion dollars in R&D has halved approximately every nine years since 1950. ~ learn more
The dawn of the GBO (Growth Buyout). A slide deck from Slow ventures that’s worth reading quickly, as it’s already a year old. “Industries will be transformed by software via new players competing on the basis of proprietary technology/IP. For […]
The Chicago River’s first open-water swim coming soon. “Signs of the river’s better health include visits from “Chonkosaurus,” a giant snapping turtle who’s a global social media sensation. Chicago is so optimistic about the river’s improvements that the city plans […]
Microsoft launches Copilot AI function in Excel, but warns not to use it. I certainly am not yet ready to trust LLMs with my spreadsheets. “However, Microsoft specifically warns not to use it for “any task requiring accuracy or reproducibility,” […]
Padel leaving pickleball in the dust? Here’s a race I don’t have a horse in. “Padel, for the uninitiated, is like pickleball’s cooler, jet-setting cousin. It’s a racket sport played on a turf or carpet court about the size of […]
List of biotech founders and drug hunters who were unlikely to succeed. And yet they did! ~ learn more
Understanding global events. “These 20 lessons, when taken together, provide a great framework for understanding just about every single issue on the global menu today. They also provide some warnings for how things might evolve and clues for how we […]
We can already stop climate change. I’ve long believed that humanity has all the technology we need, but humans so far lack the will. It’s great when someone else spells it out more clearly than I ever could. “If you […]
Treasured forest fungus fights inflammation and stifles cancer cells. Researchers have unearthed a potent compound from a rare Taiwanese fungus that could block inflammation and halt cancer cell proliferation. “It’s a new discovery from a treasured fungus that has long […]