under the microscope

One-shot gene editing for LDL.

One-shot gene editing for LDL. “One dose of VERVE-102 led to dose-dependent, substantial, and sustained reductions in PCSK9 and LDL cholesterol levels.” It is a phase 1 study in 35 people, with LDL reductions up to 62% at the highest […]

retail therapy

Ford’s IPO was a circus.

Ford’s IPO was a circus. “The syndicate will include just about everybody who’s in the business and who isn’t, or hasn’t been, in jail,” a Blyth vice-president told John Brooks. In 1956, Ford’s IPO needed a 722 firm syndicate, mailed […]

better doing

Can we have Friday off?

Can we have Friday off? Alas, probably not, because the human competitive game is relative not absolute. “If AI is going to 10x our productivity across the board, that means that I should be able to produce the same amount […]

tech, startups, internet

Half a billion on Claude.

Half a billion on Claude. “An AI consultant tells Axios one of their clients recently spent half a billion dollars in a single month after failing to put usage limits on Claude licenses for employees.” Considering my experience once spending […]

oh, chicago

Illinois legislature may have lost its mind.

Illinois legislature may have lost its mind. They’ve passed a budget bill, pending Governor Pritzker’s signature, that will tax each crypto transaction (exchange, transfer, or storage) by IL taxpayers 0.2% of value. Is this the most aggressive thing any state […]