under the microscope

A new technique to remodel the gut microbiome

Peptides! “Instead of trying to kill harmful bacteria, or transplant beneficial bacteria, this hypothesis imagines remodeling, or reconstructing, a dysfunctional microbiome into a healthy one by using highly targeted peptides that can affect a broad number of different bacteria in […]

retail therapy

The direct-to-consumer playbook is a trap

“It goes without saying that I’m bearish on DNVBs as a whole. As a whole, the industry tends to rely upon left-brain operators with systems and definite plans. But, I’m bullish on the challenger brands who’ve figured out that winning […]

to your health

What’s the point of a primary care doctor?

“They seem to exist entirely to funnel patients to more expensive specialists — but it may be the consumer, not the healthcare industry, who’s really to blame for this, and we’re suffering as a result.” | learn more

tech, startups, internet

The founder’s guide to markets

Markets matter for startups, so founders should pick great ones! “Problem is, there are no clear frameworks to figure out what a great market is. Traditional advice is to target markets that are large and/or growing fast. That’s vague. So, […]