Meet targeted protein degraders. “Targeted Protein Degraders (TPDs) are a revolutionary class of drugs that hijack the cell’s natural waste disposal system to eliminate disease-causing proteins, rather than just inhibiting them.” By leveraging the cell’s own machinery, TPDs promise potent […]
Cannabis reclassified to Schedule III. Weed will now be much less illegal nationally, but with plenty of gray area and contradictory laws. “Trump ordered agencies to begin the formal process of reclassifying cannabis as a drug with medical value and […]
To get more effective drugs, we need more human trials. “Even if approval requirements were relaxed, the underlying need would remain: we still have to learn, through testing in humans, which treatments are effective and which are not.” Clinical development […]
Most problems are people problems. “Most technical problems are really people problems.” In tackling technical debt, it’s often the human issues—such as outdated habits, unclear requirements, and unrealistic deadlines—that are the root causes. ~ learn more
The trap of pure incentive thinking. “When you start seeing every human interaction as a game-theoretic puzzle, you lose access to information that matters.” By reducing relationships to mere transactions, you risk losing out on genuine partnerships and trust. ~ […]
Has the cost of building software just dropped 90%? “AI Agents … massively reduce the labour cost of developing software.” This transformative shift is due to agentic coding, which is streamlining processes that previously required entire teams, reducing project timelines […]
Hack reveals the phone farm flooding TikTok with Al influencers. “The hacker also shared a list with me of more than 400 TikTok accounts Doublespeed operates. Around 200 of those were actively promoting products on TikTok, mostly without disclosing the […]
The $1B Al company training ChatGPT, Claude & Gemini. Surge AI, with fewer than 100 employees, “surpassed $1 billion in revenue last year, completely bootstrapped—the fastest company in history to reach this milestone.” This is an opinionated interview with Edwin […]
Al Goldstein tells the Pangea Properties story. This comes from a fantastic entrepreneur who saw opportunity where everyone else saw risk. “In late 2008 (a full month after I officially left Enova), while banks were imploding, we started buying foreclosed […]
Predicting murder without a totalitarian state. Chicago’s data-driven approach suggests “murder can be predicted and we can prevent it from happening.” Recent records forecasted shooting risks accurately, with a shocking 13% of high-risk individuals getting shot within 18 months. ~ […]