under the microscope

There are five (or more) variants of Alzheimer’s.

“It’s plausible that this not only explains some of the differences we see in how Alzheimer’s progresses, but also signals the need to treat each variant differently, potentially explaining the high failure rate in finding successful treatments up until now.” ~ learn […]

under the microscope

What if we could make CAR-T cells inside the body?

CAR-T therapies have operational scaling challenges (see above). Maybe viral vectors can circumvent those challenges by modifying your T cells while they’re still inside a patient. “Scientists are devising ways to edit the genomes of immune cells without having to […]

under the microscope

CAR-T hype faces infrastructure reality check.

Scientists invented a cancer therapy that is incredibly effective for certain cancers, but quite difficult to administer. “To make CAR-T therapies, the patient’s own T cells are extracted during a two-day process called apheresis. Manufacturers then alter the cells for […]

retail therapy

Mindsets of modern midlife women.

Commissioned by consumer VC firm Listen Ventures, this report focuses on women roughly ages 37 to 62. “The goal of this body of work is to unpack the mindsets that define midlife womanhood in the US in a consumer-obsessed way […]

to your health

The story of Novo Dordisk, maker of Ozempic.

This is a roughly 4-hour epic history of the most valuable company in Europe. “Once we dug further, we quickly realized this company has it all: an incredible 100+ year history filled with Nobel Prizes, bitter personal rivalries, board room […]

better doing

An interview with Tony Robbins.

The podcast host Shaan Puri went to one of Robbins’ seminars years ago that impacted his career. His excitement shines through this great interview. “Tony has built a $7 billion dollar empire and helped people like Ray Dalio, Connor McGregor […]

better doing

There are no statistics in the Kingdom of God.

A point on the practical limitations of statistics and p values and such. “Hey dude, remember that statistics are just a tool for distinguishing signal from noise. If we really knew what was going on, we wouldn’t need statistics. It’s […]

tech, startups, internet

The agent economy and economic growth.

Rob May looks somewhat far into the future (I think?) and comes up with an interesting scenario to consider. “Once this happens, you can see an economy growing among agents. Agents that collect unique interactions and data sets will sell […]