Magic mushrooms’ remarkable impact on Alzheimer’s patient. “Approximately 19 h post-administration, spontaneous autobiographical speech emerged.” A Frontiers in Neuroscience case report describes a woman with advanced Alzheimer’s who showed days to weeks of temporary improvements after a high-dose psilocybin mushroom session, […]
Some people resist GLP-1 drugs. “More GLP-1 was needed to have the same biological effect, meaning they were resistant to GLP-1.” Stanford-led researchers found about 10% of people carry PAM gene variants tied to weaker blood sugar improvements on GLP-1 […]
Universal mortality signatures. Dense reading. The important bit is that researchers found a couple genes across multiple species that highly correlate with aging. “We developed rodent multi-tissue clocks of chronological age and expected mortality and decomposed them into co-regulated modules […]
Stories without amplification are hobbies. “Stories without amplification are hobbies.” Avinash Kaushik’s take on TikTok: organic reach hits a ceiling, so you need to pay to amplify the right creator stories, at real scale. ~ learn more
Grindslop. “In a grindslop company, the hours are the output.” Will Manidis draws a clean line between hard companies that work long hours to build something, and a darker version where suffering becomes the product and gets performed for status. […]
The new career flex. “Now, the real flex is going back to being an Individual Contributor.” Elena Verna argues the ladder got weird when headcount became the signal of impact, and introduces the “High-Impact Individual Contributor” who can ship end-to-end […]
Fable-5 (Mythos) has already been jailbroken. “it’s hard to get explicit names of harms like “Meth Recipe,” but getting uplift on the process itself, like birch reduction method/reductive-amination (classic meth synthesis pathways), is much more doable.” A thread on how […]
Safety built into LLMs creates new risks. “malware developers added nuclear & biological weapons text to to their spyware. Goal? To trigger LLM safety refusals… so that their spyware wouldn’t be analyzed by an AI security scanner.” ~ learn more
The Al trap that is quietly wiping out angel investors. “Most AI startups do not sell software. They sell outcomes powered by rented intelligence.” Every inference has a bill attached, and SaaS heuristics don’t apply to “AI” unit economics. ~ […]
Watch your music hallucinate. “…and anyone who’s ever wanted to watch their music hallucinate!” Pliny the Liberator is shipping ENTHEA, a one-file, zero-deps visualizer where “every mode is real math, cited in-app. receipts, not vibes.” ~ learn more