Pavel Sokolovsky

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Feb 4, 2024

GLP-1 weight-loss drugs may pivot to treat Alzheimer’s.

Interesting research from the University of Toronto, which has a strong legacy and brand in this field. In ironic and stark contrast to the critical take linked above. “In yet another surprise attribute of the new class of obesity drugs, scientists have found that GLP-1 receptor agonists can…

Feb 4, 2024

A 50-year battery that degrades into copper.

“This breakthrough technology has the potential to revolutionize electronics by eliminating the need for chargers or portable power banks. Devices powered by these nuclear batteries could operate continuously without degradation in capacity or lifespan, unlike traditional Li-ion batteries. Imagine drones that can fly non-stop, phones that never need…

Feb 4, 2024

Tim Ferris warns there are no biological free lunches.

So cool it on the extra testosterone, bro. “It’s alarming how many folks now treat “T” or “TRT” (testosterone replacement therapy) as something akin to taking a multivitamin, when they never would have considered taking androgenic-anabolic steroids (AAS) a few years earlier. Like Patagonian toothfish has become Chilean…

Feb 4, 2024

A critical take on GLP-1s.

“The Ozempic argument is that we can improve health by curbing obesity. Unfortunately, Ozempic is just another example of modern medicine’s tendency to silo chronic diseases into “treatable” conditions. This paradigm has been a universal failure: heart disease has risen as we prescribe more statins, diabetes has risen…

Feb 4, 2024

The big three causes of burnout.

This is a brief and interesting assessment. “I’ve found it’s best to think of burnout not as a disease but as a symptom, with many different etiologies. The big three: permanent on-call, broken steering, and mission doubt.” ~ learn more

Feb 4, 2024

Spaced repetition memory tips.

“The single biggest change is that memory is no longer a haphazard event, to be left to chance. Rather, I can guarantee I will remember something, with minimal effort: it makes memory a _choice_.” ~ learn more

Feb 4, 2024

Cafe owner sues Meta for $100, wins in state Supreme Court.

“Despite Facebook hiring several law firms to defend their case, Soldati, representing himself, was able to successfully argue Meta/Facebook committed a breach of contract and that they were not immune under the Communications Decency Act. Soldati argued that by deleting his account with no explanation or warning, Meta…

Feb 4, 2024

Standard issue AI.

“Small-language models are coming. The consensus within the data ecosystem is that many will start with more expensive large-language models which are robust to many types of questions, but perhaps too expensive to run for most applications at scale.” ~ learn more

Feb 4, 2024

One of the first post-ban ADUs in Chicago.

“Created by Via Chicago Architects × Diseñadores and interior designer Anne Rezac, the coach house is one of the first to be built under Chicago’s ADU ordinance, which officials say intends to expand housing access by increasing the stock of ADUs and opening a path to legalization for…