Pavel Sokolovsky

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under the microscope · Jan 2025

The most enigmatic structure in cell biology: the Vault.

This is pretty cool to look at — click thru just for animation. “Often missing from science text books due to the mysterious nature of their existence, it has been 40 years since the discovery of these giant, half-empty structures, produced within nearly every cell, of every animals, on the planet.” ~ learn more

retail therapy · Jan 2025

Cannabis companies piling into hemp THC-infused beverages.

They sell legal weed in so many places now. I even saw a vending machine in Austin. The regular kind of weed is still very much banned in Texas, but this new stuff is unregulated… ~ learn more (free login required)

retail therapy · Jan 2025

Will the unions impact Amazon?

There’s threats of strikes at 7 facilities this week (or now?). “The International Brotherhood of Teamsters said unionized workers at facilities in New York City; Skokie, Illinois; Atlanta, San Francisco and southern California will join the picket line to seek contracts guaranteeing better wages and work conditions.” If you’re wondering, Amazon is almost entirely non-unionized. “A spokesperson for Amazon said the Teamsters union had for more than a year claimed…

to your health · Jan 2025

A special HSA edition of 5HT.

This is really good. “Let’s start with the good. The idea behind HSAs is a fundamentally good one. Introduced in 2003 as part of the Medicare Modernization Act (which also defined the guidelines for high deductible health plans, or HDHPs), HSAs were meant to improve on medical savings accounts, which were only available to people who were self-employed or employees at small businesses.” ~ learn more

to your health · Jan 2025

The “New Ozempic” falls short.

If you wondered why the NVO stock (see above) was down almost 20% yesterday, look no further. “[Its] experimental diabetes and weight-loss drug CagriSema fell short of expectations. The drug did not achieve the projected 25% average weight loss anticipated by the company and analysts. Instead, patients in the phase 3 clinical trial lost an average of 22.7% of their body weight after 68 weeks on the medication.” ~ learn…

to your health · Jan 2025

Compounders of off-brand Zepbound lose a product line.

The official FDA shortage is over, and compounders have 60-90 days to stop violating Eli Lilly’s patent protection. “The ruling also previews what will happen when semaglutide — the active ingredient in Novo Nordisk’s (NVO -17.43%) Ozempic and Wegovy — comes off the administration’s drug shortage list.” ~ learn more

tech, startups, internet · Jan 2025

Counting the OOOMs.

Hard not to be awed reading this. Teaser: “AGI by 2027 is strikingly plausible. GPT-2 to GPT-4 took us from ~preschooler to ~smart high-schooler abilities in 4 years. Tracing trendlines in compute (~0.5 orders of magnitude or OOMs/year), algorithmic efficiencies (~0.5 OOMs/year), and “unhobbling” gains (from chatbot to agent), we should expect another preschooler-to-high-schooler-sized qualitative jump by 2027.” ~ learn more

tech, startups, internet · Jan 2025

AND check out the Truffle-1.

“Truffle is driven by: > A Mixture of Models (MoM) acting like a CPU; > An application stack that looks like OpenAI Gym Environments; > A 64GB Orin in a glowing case … Local AI also means Infinite Inference Time Compute. Imagine being able to think for 6 months on a hard prompt but paying $0 in inference cost.” ~ learn more

tech, startups, internet · Jan 2025

NVIDIA’s Jetson Orin Nano.

Watch Jensen Huang pitch the company’s new $249 consumer AI device from the comfort of his kitchen. For real, watch it. ~ learn more

tech, startups, internet · Jan 2025

Up to $3,500 per task.

This knocked my socks off. “The new model is good at reasoning in mathematical and programming domains. It scores really well on a particular benchmark called ARC-AGI, which is above the average human. Spend more money on it, up to $3,500 per task, and it approaches the performance of a STEM graduate.” ~ learn more