under the microscope

Send in the senolytics

“Despite early failures in the clinic, the idea of anti-aging therapies that purge the body of dying cells is gaining traction with a raft of startups now focused on senescence.” I was surprised to learn there’s a senolytic for skincare currently on […]

under the microscope

Gene therapy, absolutely and for real

“This weekend brought some really significant news in the long-running effort to use gene editing to treat human disease. As most readers will have heard, Boston Children’s Hospital and a Vertex/CRISPR effort both published papers in the NEJM addressing sickle-cell […]

under the microscope

Manipulating the microbiome in plants and humans

I only recently learned about Flagship Pioneering and I have a small crush on them. They’ve founded over 100 companies, including Moderna (a name you’re hearing often in vaccine context), with 22 IPOs since 2013. Here’s them on plants: “Plants […]

under the microscope

Can patients’ gut microbes help fight cancer?

“Only 30%-40% of cancer patients respond to immune checkpoint inhibitor (CPI) therapies.” This article features several groups who, “are betting that microbiome-based therapies can help more patients respond to immunotherapies and become one of the biggest breakthroughs in cancer treatment […]