on the blockchain

2023 crypto developer report.

One of the lines of thinking I’ve embraced in the past was that when thousands of smart engineers work at something, magical things can happen. That remains true. “While developers overall are down 24%, the most valuable segment of developers […]

on the blockchain

Going post-crypto.

It’s not all sunshine and sparkles. “You can go down the rabbit hole into crypto. This is a post about getting out.” ~ learn more

teaching the kids

Schools repealing ChatGPT bans.

This NYT article discusses a few public school districts who have done an about face on their earlier bans of the technology. “Administrators say they are simply taking a pragmatic view: Students will need to learn how to prompt chatbots […]

under the microscope

There are five (or more) variants of Alzheimer’s.

“It’s plausible that this not only explains some of the differences we see in how Alzheimer’s progresses, but also signals the need to treat each variant differently, potentially explaining the high failure rate in finding successful treatments up until now.” ~ learn […]

under the microscope

What if we could make CAR-T cells inside the body?

CAR-T therapies have operational scaling challenges (see above). Maybe viral vectors can circumvent those challenges by modifying your T cells while they’re still inside a patient. “Scientists are devising ways to edit the genomes of immune cells without having to […]

under the microscope

CAR-T hype faces infrastructure reality check.

Scientists invented a cancer therapy that is incredibly effective for certain cancers, but quite difficult to administer. “To make CAR-T therapies, the patient’s own T cells are extracted during a two-day process called apheresis. Manufacturers then alter the cells for […]

retail therapy

Mindsets of modern midlife women.

Commissioned by consumer VC firm Listen Ventures, this report focuses on women roughly ages 37 to 62. “The goal of this body of work is to unpack the mindsets that define midlife womanhood in the US in a consumer-obsessed way […]

to your health

The story of Novo Dordisk, maker of Ozempic.

This is a roughly 4-hour epic history of the most valuable company in Europe. “Once we dug further, we quickly realized this company has it all: an incredible 100+ year history filled with Nobel Prizes, bitter personal rivalries, board room […]