“The term Cali Sober can be traced back to a 2019 Vice article, by a writer who quit all drugs except marijuana and certain psychedelics when she moved from New York to California.” ~ learn more
“In 1953, aged 27, Paul Janssen set up the research laboratory on the third floor of his parents’ Belgian drug import firm from where he would grow his eponymous pharmaceutical company. In the years between the 50s and 90s when […]
“As the historian David Courtwright notes in his book Forces of Habit, the past five centuries have been profoundly shaped by the rise of several drugs which have one big thing in common: they became global commodities during the early […]
“Early results of this reform effort, the first of its kind in any state, are now coming into view, and so far, they are not encouraging. State leaders have acknowledged faults with the policy’s implementation and enforcement measures. And Oregon’s […]
“One of the uncomfortable truths about the pharmaceutical industry is that most approved drugs (~55%) don’t make enough money to recoup their development costs. The distribution of drug profits is “fat-tailed”, and the profits from a small fraction of drugs […]
“The business plan is supply chain transparency: buying drugs from wholesalers, packaging them, adding a 15% markup and selling to pharmacies, clinics and health systems. The goal, according to the website, is to produce “low-cost versions of high-cost generic drugs.”” | learn […]
A brief exploration of NNT (number needed to treat) and NNH (number needed to heal). | learn more
Senolytics are the class of drugs that target senescent cells (so-called “zombie cells”). While the basis for using these drugs to delay, prevent or reverse aging is still limited, there’s certainly a lot of excitement in the field. Also, there’s […]
Something happened in the early 1970s that led to dozens of unexplained trends. Many blame the US dropping the gold standard. This author blames a different policy that Nixon signed into law. This is a fascinating read. “New drugs lead to scientific […]
Michael Pollan suggests we’ll need a cultural framework to guide our nation’s relationship with drugs now that “just say no” is no longer our guiding principle. He points to the many indigenous cultures that have used ritual to keep useful […]