“One of the uncomfortable truths about the pharmaceutical industry is that most approved drugs (~55%) don’t make enough money to recoup their development costs. The distribution of drug profits is “fat-tailed”, and the profits from a small fraction of drugs […]
“The business plan is supply chain transparency: buying drugs from wholesalers, packaging them, adding a 15% markup and selling to pharmacies, clinics and health systems. The goal, according to the website, is to produce “low-cost versions of high-cost generic drugs.”” | learn […]
A brief exploration of NNT (number needed to treat) and NNH (number needed to heal). | learn more
Senolytics are the class of drugs that target senescent cells (so-called “zombie cells”). While the basis for using these drugs to delay, prevent or reverse aging is still limited, there’s certainly a lot of excitement in the field. Also, there’s […]
Something happened in the early 1970s that led to dozens of unexplained trends. Many blame the US dropping the gold standard. This author blames a different policy that Nixon signed into law. This is a fascinating read. “New drugs lead to scientific […]
Michael Pollan suggests we’ll need a cultural framework to guide our nation’s relationship with drugs now that “just say no” is no longer our guiding principle. He points to the many indigenous cultures that have used ritual to keep useful […]
“Over the last four years, Neta Raab and Ido Bachelet have received hundreds of padded cardboard boxes containing frozen poop from wild animals on five different continents.” | learn more
Sending pallets of cash across the border is risky. So, what’s a drug cartel to do? | learn more
Author: Thomas Hager Before a drug can change the world, it must be discovered. Ten Drugs tells stories of these fateful discoveries. Taken together, they paint a picture of humanity’s long and complicated relationship with drugs. We often hear polarized […]
Hope is on the horizon for a new weapon against antibiotic resistance: “magnetic nanoparticles that physically tear them to shreds.” | learn more