Recent advances in Alzheimer’s disease. “In this review, we summarize the most recent updates in AD research on pathologic disease mechanisms and therapeutic strategies, highlighting advancements in apolipoprotein E (APOE) biology, neuroimmunology, biomarker discovery, and initial experience with new disease-modifying […]
The cancer Alzheimer’s disease paradox. “paradoxically, the risk of AD in patients with cancer is reduced by 25–35%. Conversely, the risk of cancer in patients with AD is halved.” ~ learn more
Guy in garage lab testing a new Alzheimer’s drug. “I designed and synthesized PAC-832 in a chemistry lab I built in my garage.” Douglas Yao walks through PAC-832, “the world’s first selective GalR1 antagonist,” plus why targeting galanin signaling might […]
Babylon is on a quest to cure Alzheimer’s. From the Relentless podcast: “My first interview with Sacha Schermerhorn, Founder & CEO of Babylon Bio.” The first ~30 minutes of this are a fast-paced overview of the history and state of […]
Magic mushrooms’ remarkable impact on Alzheimer’s patient. “Approximately 19 h post-administration, spontaneous autobiographical speech emerged.” A Frontiers in Neuroscience case report describes a woman with advanced Alzheimer’s who showed days to weeks of temporary improvements after a high-dose psilocybin mushroom session, […]
How exercise can lower Alzheimer’s risk. “Now, closely examining cells from geriatric animals’ blood-brain barriers, the researchers noticed that a damaging protein, known as TNAP, proliferated on the surface of those cells in far greater numbers than on cells from […]
Mouse Alzheimer’s reversed in new study. “Remarkably, not only did preserving NAD+ balance protect mice from developing AD, but delayed treatment in mice with advanced disease also enabled the brain to fix the major pathological events driven by the disease-causing […]
Cancer may help protect the brain against Alzheimer’s. Cancer and Alzheimer’s disease are two of the most feared diagnoses in medicine, but they rarely strike the same person. Now, a study reveals that a protein from cancer cells might infiltrate […]
“A look inside the brains of engineered mice suggests therapies might need to target two key proteins — tau and amyloid-beta — at the same time.” This is from 2019. I’m not sure where this idea has led researchers. ~ learn more
“Yes,” says Dr. Donald Weaver, co-Director of the Krembil Brain Institute and author of new research published in the peer-reviewed journal, Alzheimer’s & Dementia. “We don’t think of Alzheimer’s as fundamentally a disease of the brain. We think of it […]